Evidence-based Product Development

Development

Evidence-based Product Development

Collaboration with Medical Institutions

For many years ITO has been conducting research on functionality of Vitamin C derivatives and other cosmetic ingredients with collaboration with medical institutions.
Product development to achieve both safety and efficacy is realized through clinical tests supported by dermatologists and plastic surgeons.

Collaboration with Medical InstitutionsCollaboration with Medical InstitutionsCollaboration with Medical InstitutionsCollaboration with Medical Institutions

Efficacy Evaluation

Efficacy assessment tests are conducted daily at the lab of ITO to develop evidence-based products. In the course of product development, functionality of cosmetic ingredients to the final product are investigated thoroughly using in vitro test with cells and clinical tests.

Efficacy Evaluation

Formulation Development

Cosmetic ingredients which pass our efficacy and safety evaluation are used to create preproduction prototypes. This phase is repeated many times until satisfactory preproduction prototype is created. Stability test and sensorial assessment are also implemented before final formula which passes ITO’s severe criteria is put into production.

Formulation Development

Conference & Exhibition

Domestic

2021

In 2021, we plan to conduct seminars on the following domestic conferences.

2021 June 10 (Thurs.) to 13 (Sun.)
Hotel Chinzanso Tokyo
The 120th Annual Meeting of the Japanese Dermatological Association
2021 May 10 (Wed.) to 21 (Fri.)
Pacifico Yokohama
The Cosmetic Ingredients &Technology Exhibition Japan (CITE JAPAN)
Official cite of CITE JAPAN
 → https://www.citejapan.info/en/

GO-VC® won silver prize in technology category for CITE JAPAN 2021 Award, which was judged by novelty, impact, and industry contribution.
About CITE JAPAN 2021 Award
→ https://www.citejapan.info/en/award.html


We also conducted seminars on GO-VC® and Nanosphere® for Technology Forum.
1) May 19, 2021 13:15 to 13:45 (Room G)
Title: The function of Nanosphere®, oil-rich nanocapsule whose membrane is composted of amphiphilic vitamin C/E derivatives


【Abstract】
Nanosphere® is a nanocapsule whose outer shell is made from vitamin C/E derivatives and expected to have the synergy effects between the encapsulated components and vitamin C/E derivatives composing the outer shell. The outer shell of Nanosphere® is composed of several vitamin C/E derivatives, of which GO-VC® is particularly characteristic. GO-VC® is a highly stable vitamin C derivative where glycerin and octanol are introduced to vitamin C and could show various skin physiological effects such as skin barrier function-enhancing effect. Therefore, Nanosphere® whose outer shell is made from GO-VC® is expected to show various skin physiological effects, and these effects could be further enhanced by synergies with the encapsulated components. In addition, Nanosphere® could enhance the stability and skin permeation of encapsulated components and has clinical test data on various skin troubles by dermatologists. In this seminar, we will introduce the various functions of Nanosphere® in detail.

2) May 20, 2021 12:30 to 13:00 (Room A)
Title: The antibacterial activity and the skin barrier function-reinforcing effect of GO-VC®, an amphiphilic vitamin C derivate: For preventing chapped hands by using alcohol-based hand sanitizers


【Abstract】
GO-VC® is a highly stable amphiphilic ascorbic acid derivative where glycerin and octanol are introduced to ascorbic acid and has been confirmed to have antibacterial and antiviral activities. Therefore, the addition of GO-VC® to the alcohol-based hand sanitizers is considered to lead to the enhancement of the antibacterial and antiviral activities. Furthermore, GO-VC® could reinforce the skin barrier function through the up-regulation of tight junctions, resulting in the suppression of skin dryness. Therefore, GO-VC® is suitable for the care of skin roughness and dryness after using alcohol-based hand sanitizers. In addition, GO-VC® has been confirmed of clinical effects on the spots, wrinkles, and acne by dermatologists and their action mechanism, and is also recommended to add to cosmetic products for anti-aging. In this seminar, we will introduce the various effects of GO-VC® on the skin in detail.

2021 April 14 (Wed.) to 16 (Fri.)
Hotel Chinzanso Tokyo
The 64th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

2020

2020 November 9 (Mon.) to 10 (Tue.)
The 50th Annual Meeting of Japanese Society for Wound Healing
Online Meeting
2020 August 26 (Wed.) to 28 (Fri.)
Port Messe Nagoya
The 63rd Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery
Hybrid Meeting (Local and Online)
2020 June 4 (Thur.) to 7 (Sun.)
The 119th Annual Meeting of the Japanese Dermatological Association
Online Meeting

*For the above three meetings we conducted seminars on the following academic and clinical topics:
The effect of retinol-encapsulated ascorbic-acid-derivative-nanocapsules on the skin troubles such as wrinkle and hyperpigmentation
The skin-lightening mechanism of GO-VC, a new amphiphilic ascorbic acid derivative

International

2021

2021 March 24 (Wed.) to 26 (Fri.)
Shenzhen Convention & Exhibition Center
Personal Care and Homecare Ingredients (PCHi)

2020

2020 June 4 (Thur.) to 7 (Sun.)
The 31st International Federation of Societies of Cosmetic Chemists (IFSCC) Congress 2020 Yokohama
Online Meeting

Presented a poster on ‘2-O-glyceryl-3-O-octyl ascorbate (GO-VC), an amphiphilic ascorbic-acid derivative, enhances skin hydration by reinforcing the barrier function through the up-regulation of tight junctions’.

Publication

Personal Care Global  July 2021
Personal Care Global July 2021
‘Diverse skin benefits of an amphiphilic AsA derivative'

Personal Care Global May 2021
Personal Care Global May 2021
Information about our presentation of GO-VC was introduced
as one of the highlighted technology forum seminars of CITE JAPAN 2021
held in May at Yokohama Japan.

FRAGRANCE JOURNAL 2020 November
FRAGRANCE JOURNAL 2020 November
Effect of GO-VC on the epidermal barrier function of tight junctions

FRAGRANCE JOURNAL 2015 September
FRAGRANCE JOURNAL 2015 September
Clinical effect of amphiphilic vitamin C derivative GO-VC

PERSONAL CARE 2013 November
PERSONAL CARE 2013 November
A new nonionic ascorbic acid derivative